Biophysical analysis in drug discovery is an essential research effort that helps researchers understand the interactions between drugs and biological macromolecules, comprehend the mechanism of action of drugs, and provide decision support for drug development. Atomic force microscopy (AFM) is a microscope that provides high-resolution biophysical information and is widely used in drug discovery and development.

CD BioSciences has an Atomic Force Microscopy (AFM) platform that provides specialized services for biophysical analysis in drug discovery. We have a professional scientific team that has mastered the application and development of AFM technology, as well as a wealth of experience in drug discovery and development. Meanwhile, our advanced instrumentation and high precision and sensitivity enable us to provide high-quality data and accurate analysis.

Service Options for AFM-Based Drugs Biophysical Analysis

• Structural analysis of drug molecules
  We can apply AFM technology to study the structure, conformation, and interaction of drug molecules to provide reference and decision support for drug design.
• Crystalline structure analysis of drugs
  We can study the crystalline structure of drugs and biomolecules through AFM technology, which helps researchers to design more effective drug molecules and drug carriers and improve drug efficacy and drug transport efficiency.
• Intermolecular interaction analysis
  We use AFM technology to study the interactions between drug molecules and biomolecules, such as the interactions between receptors and ligands, in order to reveal the mechanism of action of drugs and provide decision support for drug design.
• Transport and release analysis of drug molecules
  We can use AFM technology to study the transport, release, and metabolism of drug molecules in living organisms to support drug development and therapeutic programs.

Applications

• Drug development
  AFM technology can characterize drug molecules in various aspects such as morphology, structure, and function, which can provide important support and guidance for drug development.
• Drug safety evaluation
  AFM technology can provide powerful data support for the toxicological evaluation of drugs, and test and verify the safety and stability of drugs.
• Drug synthesis and quality control
  AFM technology can characterize and evaluate the intermediates and products of drug synthesis, and improve the efficiency and quality of drug synthesis and quality control.

CD BioSciences offers AFM-based drug biophysical analysis services to help researchers obtain important information on the structure, interaction, and function of drug molecules, understand the mechanism of action and effects of drugs, and provide decision support for drug development and therapeutic options. Our services can help you achieve a variety of objectives such as accelerating drug development, improving drug efficacy, and reducing adverse effects. We welcome customers with related needs to contact us, and we will provide you with professional services and technical support.

• Drug Design Based on X-ray Crystallography
• Thermodynamic Characterization of Biomolecular Interactions
• Target Binding Analysis by HDX-MS
• Binding Affinity Measurement by MST
• Protein Stability Evaluation by TSA
• Fragment Screening Based on WAC
• Hit Identification by NMR-based Techniques
• Qualification of Targeting Protein-Protein Interactions
• Measurement of Ligand Binding Kinetics
• Identification of Small-Molecule Aggregation
• Analysis of Free Energy Calculations
• Modeling of Scaffold Hopping Transformations
• Cellular Imaging Service for Drug Discovery