CD BioSciences is dedicated to the development of techniques for the detection of neurotransmitters, particularly in vivo neurotransmitter tracking methods for the real-time diagnosis of brain diseases. Our neurotransmitter detection services help our clients to study the release and regulation of various neurotransmitters in physiological and pathological conditions, making it possible to ultimately explain the working mechanisms of the human brain.

Introduction

Neurotransmitters are small molecules that transmit neural signals through the synapses between neurons. Neurotransmitters and proteins are interconnected to enable neural signal transmission to proceed smoothly. Abnormal neurotransmitter levels and distribution can trigger disease, leading to a variety of clinical features including paroxysmal disorder, hypoxic-ischemic encephalopathy, movement disorder and others. Precise studies of the dynamics of neurotransmitters are important for understanding the function of the nervous system and for studying the pathogenesis of neurological disorders.

There are hundreds of neurotransmitters in the human brain. The complexity of the release patterns of different types of neurotransmitters, the temporal and spatial differences, and the types of receptors and their distribution make it much more difficult to accurately detect neurotransmitter release. With the development of new genetic tools and microscopic imaging techniques, the development of effective real-time in vivo neurotransmitter detection techniques has been promoted, laying the foundation for studying the release and regulation of various neurotransmitters under physiological and pathological conditions.

Fig.1 (a) The mechanism of fluorescence imaging for measuring 5-hydroxytryptamine and (b) Fluorescence probe for monitoring acetylcholine in vivo. (Su, 2020)

Our Services

We have developed a variety of neurotransmitter real-time in vivo assays to help clients assess metabolism and measure neurotransmitters in vivo. Our services include but are not limited to:

• Quantitative analysis of amino acid neurotransmitters.
• Quantitative analysis of biogenic amine neurotransmitters.

• Detection of catecholamines.
• Detection of indoleamines.
• Detection of histamine.

• Quantitative analysis of purinergic neurotransmitters.

• Detection of adenosine triphosphate (ATP).
• Detection of adenosine.

• Detection of acetylcholine.
• Detection of neuropeptides.
• Detection of gasotransmitters.

Technologies We Provide to Measure Neurotransmitters In Vivo

The techniques we provide include but are not limited to:

Advantages of Our Technologies

• High specificity and sensitivity
• High temporal-spatial resolution and rapid response
• Easy operation and low cost

CD BioSciences has established a variety of advanced techniques for measuring neurotransmitters in vivo to provide quantitative neurotransmitter analysis services to our clients. We offer different techniques or combinations of techniques to obtain comprehensive information on neurotransmitters according to the specific needs of the client's project. If you would like more details, please feel free to contact us.

Reference

1. Su, Y.; et al. Real-time in vivo detection techniques for neurotransmitters: a review. Analyst. 2020, 145(19): 6193-6210.

• Whole-Brain Imaging Based on Biophysical Technology
• Analysis of Neurotransmitter Release
• Electrophysiological Measurements of Neurons
• Analysis of Synaptic Transmission and Plasticity
• Analysis of 3D Neural Morphology
• Visualization of Neural Activity
• Structural and Functional Analysis of Neural Circuits
• Biophysical Modeling of Neural Systems