Drug screening is a step in the modern drug development process to test and obtain compounds with specific physiological activity, selecting compounds with higher activity for a specific target of action from many compounds or new compounds through standardized biophysical techniques. With the development of modern medicine and biology, drug-directed screening has been gradually applied. At the same time, with the continuous improvement of detection technology, the throughput of drug screening is also continuously improved.
CD BioSciences has established biophysical platforms, including surface plasmon resonance (SPR), microscale thermophoresis (MST), and isothermal titration calorimetry (ITC) for early-stage drug screening, which promotes the drug development process.
Applications in Drug Screening
CD BioSciences is dedicated to providing a full range of biophysical analytical services that delve into the interactions between drugs and living organisms. Through precise measurement of biological parameters such as conformation, connectivity, and affinity of molecules, we can screen drug molecules that are most likely to exert therapeutic effects.
High Throughput Screening
We can provide biophysical techniques such as surface plasmon resonance (SPR), microscale thermophoresis (MST), and isothermal titration calorimetry (ITC), which enable high-throughput screening. In addition, we utilize these technologies to evaluate many drug candidates simultaneously, allowing us to rapidly screen promising compounds, further reducing the time required to find new drugs and improving the efficiency of drug screening.
Enhanced Screening Efficiency
We can provide SPR technology, which is not limited to the detection of interactions between macromolecules, but also enables the detection of protein-small molecule and nucleic acid-small molecule interactions. Since SPR can directly reflect the strength and kinetic pattern of interactions between two molecules, it can also be used to screen protein and small molecule libraries, greatly reducing the false positive rate and significantly improving the efficiency of drug screening. In addition, our biophysical technology can be used to quickly and accurately assess drug-target protein interactions, thus helping researchers to quickly screen potential compounds from a large number of drug candidates.
Drug-target Interaction Analysis
We offer a range of biophysical techniques including SPR, MST, and ITC that can be used to obtain kinetic, thermodynamic, and structural information on drug-target interactions. This detailed information helps clients gain a deeper understanding of the mechanism of action of the drug, leading to more effective drug optimization and design.
Target Protein Detection
The technologies of our platform include SPR, MST, nanoDSF, BLI, DLS, etc. These methods can accurately control and analyze the quality, function, binding strength, and other parameters of target proteins. It is critical for determining drug-target interactions and helps screen for more effective and safer drug candidates.
Guidance of New Drug Development Direction
Through in-depth research on the biophysical properties of drug candidates, we can obtain important references and bases for the direction of new drug development, which will help pharmaceutical companies formulate more effective R&D strategies, reduce R&D costs, and improve the success rate of new drugs.
Advantages of Our Services
- Multi-dimensional. Our services provide effective drug screening support for different fields.
- Efficient. With our automated and optimized experimental processes, we can quickly screen potential drug molecules and significantly shorten the drug development cycle.
- High accuracy. Our technology platform is capable of accurately measuring drug-biomolecule interactions to assess a drug's potential efficacy.
Related Services
CD BioSciences, as an expert in the field of biophysics, strives to develop and refine advanced technologies and services that make a critical contribution to drug screening in new drug discovery and development. If you would like more information, please contact us at any time.
For research use only, not
intended for any clinical use.
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