Impedance Measurements for Biomedical Research
Biological organisms and their constituent organs, tissues and cells have unique electrical impedance characteristics, which change with the variation of composition, structure and metabolism. CD BioSciences is committed to developing technologies for impedance measurement and helping customers obtain useful biophysical parameters that can provide both insights into potential biochemical events and information about the impact of changes in cell behavior.
Background
ElectricaI bioimpedance measurement, or impedance technology, is a technique that uses the electrical properties of biological tissues and organs and their variability to extract biomedical information related to the physiological and pathological conditions of the body. This technology has many advantages, including noninvasive, harmless, inexpensive, simple operation, rich functional information, accurate measurement results and high repeatability.
Over the last two decades, several instruments and analytical methods have been developed to measure the impedance properties of biological samples. Bioelectrical impedance-based medical testing techniques are now increasingly being used in research and clinical applications such as respiratory monitoring, body composition testing, gastric kinetics and cardiopulmonary resuscitation evaluation. Although the technology is subject to a number of factors in its operation, it still occupies an important place in basic science and biomedicine research.
Fig.1 Single cell model and overview of the impedance-based high-throughput μIFC system. (Zhong, 2021)
Our Services
We are committed to providing our clients with impedance measurement services from whole-body analysis to a single cell and cellular monolayers, providing vital information for gaining insight into human physiological and pathological processes. Electrical impedance tomography (EIT) is a technique we commonly use for biomedical research. The services we provide include but are not limited to:
- In vivo measurements.
- Determination of body composition.
- Measurement of cardiac output and circulating blood volume.
- Differentiation between skin cancers and benign lesions.
- Acquisition of continuous, noninvasive images of the lungs and the distribution of the ventilation.
- Monitoring of abnormal fluid accumulation areas with edema and brain swelling.
- Impedance measurements of cells in vitro.
- Impedance measurements of individual cells.
- Impedance analysis in vitro on cell monolayers.
- Measurement of cell death in diverse experimental systems.
- Measurement of cell proliferation and cytostasis.
- Monitoring of endothelial cell junctions.
- Measurement of cell migration and invasion of cell monolayers.
Applications
- Development of impedance instruments for detecting or evaluating tumors.
- Screening for certain classes of pharmacologically active agents.
- Development of optimal treatment regimes.
Advantages
- High resolution and sensitivity instruments
- Comprehensive data analysis and minute experimental errors
- Professional and thoughtful service
CD BioSciences has developed reliable and sensitive strategies for impedance measurements to help researchers better understand human physiology and pathology. Our professional technical support and quality scientific services will make the necessary contribution to your research in the biomedical field. If you are interested in our services, please feel free to contact us for more details.
Reference
- Zhong, J.; et al. Multi-frequency single cell electrical impedance measurement for label-free cell viability analysis. Analyst. 2021, 146(6): 1848-1858.
For research use only, not
intended for any clinical use.
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