Introduction
Mass spectrometry (MS) analysis is an analytical method that achieves analytical goals by first ionizing a substance, separating the ions according to their mass-to-charge ratios, and then measuring the intensities of the various ion spectral peaks. In addition, it is a major tool for high-throughput detection and analysis of small metabolites with specialized identification capabilities.
Figure 1. Evolution of key LC/MS technology and its application in drug metabolite identification in the past 50 years. (Wen B, et al., 2015)
Working Principle
The sample is first vaporized into gaseous molecules or atoms, which are introduced to an ionization source to ionize them into charged ions. Then after acceleration into the mass analyzer (magnetic field), the ions are arranged in the order of mass-to-charge ratio size, and their intensity is measured to obtain the mass spectrum.
Features
- High sensitivity. Usually, only a few micrograms of samples are needed for a single analysis.
- Short response time and fast analyzing speed.
- It is easy to realize the coupling with gas phase and liquid chromatography, and the degree of automation is high.
- A large amount of information can get a lot of structural information, and the relative molecular mass of the sample molecules can also determine the molecular formula.
CD BioSciences is committed to providing professional mass spectrometry (MS) services to facilitate protein research and drug development.
Main Applications
Proteins are the main targets of most drugs. The rapid development of mass spectrometry-based proteomics technology enables us to analyze disease phenotypes and their regulatory mechanisms in a higher dimension. On the one hand, we can use mass spectrometry to explore the off-target effects and resistance mechanisms of drugs, thus improving the efficiency of drug discovery. On the other hand, mass spectrometry allows us to predict potential side effects and toxicity at the early stage of drug discovery, thus reducing the risk of drug discovery failure.
Mass spectrometry plays an irreplaceable role in proteomics with its advantages of high sensitivity, high resolution, and high accuracy. Our mass spectrometry technologies provide powerful tools for analyzing life processes, disease mechanisms, and drug discovery through protein identification, expression analysis, modification studies, interaction studies, structural analysis, disease marker discovery, and drug target identification.
What Can We Offer?
CD BioSciences configures advanced biophysical technology platforms and strives to provide professional mass spectrometry services to our clients. For more details, please feel free to contact us.
Reference
- Wen B, Zhu M. (2015). Applications of mass spectrometry in drug metabolism: 50 years of progress[J]. Drug metabolism reviews. 47(1): 71-87.
For research use only, not
intended for any clinical use.
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