The structure of the brain and its functions have always been an important target of research in the process of human self-awareness, while the study of the molecular mechanisms of transmission and release of neurotransmitters has been a top priority. Recent studies have revealed that neurotransmitter release is influenced by key marker protein molecules in neurodegenerative diseases. Currently, more and more studies are utilizing advanced single-molecule biophysical techniques to detect neurotransmitter release, which can help to understand further the mechanisms of neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, and Huntington's disease, and thus guide their clinical prevention and treatment.
CD BioSciences, with its well-established single-molecule biophysical technologies and rich experience, provides specialized services to lay the foundation for studying neurocognitive functions and the mechanisms of neurodegenerative diseases.
CD BioSciences has high-precision experimental techniques and equipment designed to provide specialized biophysical analysis services for revealing the complex mechanisms and dynamics involved in neurotransmitter release.
We provide fluorescence energy resonance transfer (FRET) technology to qualitatively and quantitatively detect interactions between biomolecules, and to precisely analyze the mechanism of cell membrane fusion to reveal the process of neurotransmitter release. In addition, we offer fluorescence microscopic imaging to demonstrate the dynamics of multiple proteins before and after fusion, as well as during ultra-fast membrane fusion.
We provide advanced fluorescence microscopy techniques to observe the spatial distribution of protein-protein, protein-phospholipid molecules, protein complexes, and biological membranes, as well as their real-time interactions and dynamic structural changes, which help our clients to deeply explore the mechanism of neurotransmitter release and thus advance the field of neuroscience.
We provide synaptic potential measurement technology that can accurately analyze the dependence of transmitter release on presynaptic depolarization. By measuring the amplitude of postsynaptic potentials, we can quantitatively assess the efficiency and kinetic properties of transmitter release, accelerating neurotransmitter release studies.
CD BioSciences is a biotechnology company focused on biophysical services. We are proficient in both chemistry and biophysics, and have a comprehensive biophysical platform containing a wide range of advanced technologies.